Key result
SVC myocardial sleeve >37 mm is linked to ~6-fold greater SVC firing risk during AF ablation.
Why the study?
Non-PV foci, especially from the SVC, play an important role in initiating and maintaining AF despite the utility of PV antrum isolation.
Does the length of the myocardial sleeve in the superior vena cava predict SVC firing in patients with non-valvular atrial fibrillation undergoing ablation?
Observational (n=427)
Yes
Does the length of the myocardial sleeve in the superior vena cava predict SVC firing in patients with non-valvular atrial fibrillation undergoing ablation?
Effect estimate: OR 6.39 (95% CI 3.67-11.1)
p-value: p=<0.001
An L-SVC longer than 37.0 mm and a longer SVC diameter are independent predictors of SVC firing in patients with non-valvular AF undergoing ablation.
Longer SVC myocardial sleeve length was associated with firing during AF ablation; leaves open whether imaging should guide targeted isolation.
Background Pulmonary vein (PV) antrum isolation (PVAI) has proven to be a useful strategy for radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF) worldwide. However, non‐PV foci, especially from the superior vena cava (SVC), play an important role in initiating and maintaining AF. Methods In all, 427 consecutive patients with non‐valvular AF who were admitted to our hospitals to undergo RFCA of AF using an EnSite ™ system were evaluated. The length from the top of the sinus node to the top of the myocardial sleeve of SVC (L‐SVC), longer and shorter diameter of SVC of 1 cm above of junction of right atrium and SVC, and local activation time (LAT) of SVC were measured. Then, the SVC firing was evaluated by an intravenous administration of isoproterenol and adenosine triphosphate. Results L‐SVC, longer and shorter diameter of SVC, and LAT of SVC were significantly longer in the SVC firing group than non‐SVC firing group ( P < .05). Moreover, in accordance with the L‐SVC, the frequency of the SVC firing significantly increased ( P < .001). A univariate analysis and multivariate statistical analysis revealed that L‐SVC longer than 37.0 mm (odds ratio 6.39) and longer diameter of SVC (odds ratio 6.78) were independent risk factors for SVC firing in patients with AF who underwent RFCA of AF. Conclusions In view of these findings, L‐SVC longer than 37.0 mm longer diameter SVC longer than 17.0 mm may be one of the important predictors of SVC firing in patients with AF.
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Nyuta et al. (2021) conducted an observational in Non-valvular atrial fibrillation (n=427). Length of myocardial sleeve in SVC ≥ 37.0 mm vs. Length of myocardial sleeve in SVC < 37.0 mm was evaluated on Superior vena cava firing induced by isoproterenol and adenosine triphosphate (OR 6.39, 95% CI 3.67-11.1, p=<0.001). A myocardial sleeve length in the superior vena cava longer than 37.0 mm independently predicted superior vena cava firing (OR 6.39) in patients with atrial fibrillation undergoing catheter ablation.
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