Key result
Tissue Doppler imaging and speckle tracking echocardiography demonstrated significant right ventricular systolic and diastolic dysfunction in children with dilated cardiomyopathy compared to controls.
Why the study?
Dilated cardiomyopathy is the most common heart muscle disease in children, but right ventricular function and structure using speckle tracking echocardiography needed evaluation.
Does speckle tracking echocardiography and tissue Doppler imaging detect right ventricular dysfunction in children with idiopathic dilated cardiomyopathy compared to healthy controls?
Case-Control (n=75)
Does speckle tracking echocardiography and tissue Doppler imaging detect right ventricular dysfunction in children with idiopathic dilated cardiomyopathy compared to healthy controls?
Tissue Doppler imaging and 2D speckle tracking echocardiography reveal significant right ventricular systolic and diastolic dysfunction in children with idiopathic dilated cardiomyopathy.
May support RV assessment by TDI/STE in pediatric DCM; hypothesis-generating and should not change practice without prospective validation.
Background: Dilated cardiomyopathy (DCM) refers to dilating the ventricles and dysfunction of their systolic functions (predominantly the left ventricle) with or without congestive heart failure. In children, it is the most common form of heart muscle disease. We aimed to evaluate the right ventricular functions and structure using speckling tracking echocardiography in children with dilated cardiomyopathy and correlate this parameter with other echocardiographic findings. Methods: This observational Case-Control Study was carried out on 75 subjects. They were subdivided into two groups: Group 1: 50 patients with dilated cardiomyopathy Group 2: 25 healthy children matched for age and sex. Patients were evaluated by M-mode echocardiography, Transthoracic 2DE Examination (TTE), Tissue Doppler Examination (TDE) and Speckling Tracking Technique. Results: Left ventricle (LV) and right ventricle (RV) systolic dysfunction was evidenced by a significant decrease of mitral and tricuspid annular systolic velocities and a significant decrease of LV and RV global systolic strain and a significant decrease of LV and RV Ejection fraction (EF). LV and RV diastolic dysfunction were evidenced by a significant decrease of mitral and tricuspid annular diastolic velocities (E’/A’) and a significant increase of LV and RV Myocardial Perfusion Imaging (MPI). LV and RV global strains were significantly reduced in comparison to controls, suggesting that the dilated cardiomyopathy is a diffuse disease. Conclusion: In DCM patients, RV had significant systolic and diastolic dysfunction mainly elicited by the Tissue Doppler imaging (TDI) beside LV affection secondary to the interventricular interaction. TDI and 2D-STE add value to interpreting the findings and the dependency of RV systolic and diastolic functions on each other in DCM patients.
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El-Fiky et al. (2021) conducted a case-control in Idiopathic Dilated Cardiomyopathy (n=75). Speckle tracking echocardiography and Tissue Doppler imaging vs. Healthy children matched for age and sex was evaluated on Right ventricular functions and structure. Tissue Doppler imaging and speckle tracking echocardiography demonstrated significant right ventricular systolic and diastolic dysfunction in children with dilated cardiomyopathy compared to controls.
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