Increased use of oral anticoagulants in patients with atrial fibrillation: temporal trends from 2005 to 2015 in Denmark
Key result
OAC initiation among incident atrial fibrillation patients in Denmark increased from 40-50% before 2010 to 66.5% by June 2015 (P < 0.0001 for trend), predominantly driven by NOAC prescriptions.
Population
108,410 patients with newly diagnosed atrial fibrillation at Danish hospitals and outpatient clinics between…
Design
Cohort
Authors
Discussion
Loading...
Member takes
Implication
NOAC-linked rise in OAC initiation supports wider AF anticoagulation uptake; leaves open real-world outcome effects in observational cohorts.
Study Design
Type
Observational (n=108,410)
Multicenter
Yes
Structured PICO
P
Population
108,410 patients with newly diagnosed atrial fibrillation (AF) at Danish hospitals and outpatient clinics between January 2005 and June 2015.
I
Intervention
Oral anticoagulants (OAC), including non-vitamin K antagonist oral anticoagulants (NOACs), initiated within ±180 days from date of AF diagnosis
O
Outcome
Temporal trends in the use of oral anticoagulants (OAC) as stroke prophylaxis and factors associated with OAC initiation
Main Result
p-value: p=<0.0001 for trend
The introduction of NOACs was accompanied by a significant increase in overall oral anticoagulant use for stroke prophylaxis among incident atrial fibrillation patients in Denmark.
Cite This Study
Gadsbøll et al. (2016) conducted an observational in Atrial fibrillation (n=108,410). Oral anticoagulants (OAC) was evaluated on OAC initiation within ±180 days from date of AF diagnosis (p=<0.0001 for trend). OAC initiation among incident atrial fibrillation patients in Denmark increased from 40-50% before 2010 to 66.5% by June 2015 (P < 0.0001 for trend), predominantly driven by NOAC prescriptions.