Key result
The a-m biological growth model represents growth curves as the sum of two distinct S-curves.
Why the study?
Differences arising over time within a growing population due to extrinsic and intrinsic factors lead to divergence in population growth, which may be represented as two distinct S-curves.
Biological growth curves can be mathematically modeled as the sum of two distinct S-curves representing intrinsic and extrinsic factors.
May inform cardiac growth models; hypothesis-generating pending mammalian validation.
A growing population consists of successive generations of individuals interacting with each other and their environment. At every instant, these interactions can lead to either promotion or restriction of the population growth. Thus, within a growing population, differences arise over time due to both extrinsic and intrinsic factors such as resource utilization, competition, age distribution etc. These differences can lead to divergence within the population growth. The sum of these differences is manifested as the net population growth. In this work, we propose that these differences that arise over time within a growing population can be represented as two distinct S-curves. The sum of these two S-curves results in the growth curve of a population. These differences also arise in the growth curves of a population’s attributes such as height or weight. We demonstrate this by applying the a − m biological growth model on (i) the population growth curves of Drosophila and yeast and (ii) the growth curves of the mean height of a population of sunflower plants and the mean body weight of male white rats. Finally, we also discuss the results using a coordinate system with the two distinct S-curves as the axes.
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I S Shruti (2025) studied Biological growth. a-m biological growth model was evaluated. The a-m biological growth model demonstrates that a biological growth curve can be represented as the sum of two distinct S-curves, as shown in Drosophila, yeast, sunflowers, and rats.
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