Key result
Mineralocorticoid receptor antagonists, including spironolactone, resulted in a significant reduction in blood pressure levels in patients with resistant hypertension.
Why the study?
Mineralocorticoid receptor antagonists are second-line antihypertensive drugs considered optimal add-on therapy for resistant hypertension, but their overall effects needed assessment.
Do mineralocorticoid receptor antagonists reduce blood pressure in patients with essential and resistant hypertension?
Do mineralocorticoid receptor antagonists reduce blood pressure in patients with essential and resistant hypertension?
This review confirms that mineralocorticoid receptor antagonists are effective add-on therapies for lowering blood pressure in resistant hypertension.
Supports MRAs for resistant hypertension; hypothesis-generating and requires larger trials before practice change.
BACKGROUND: Mineralocorticoid receptor antagonists are a second-line class of antihypertensive drugs, which have been accounted for as the optimal add-on therapy in the triple algorithm for the management of resistant hypertension. OBJECTIVES: To assess the effects of mineralocorticoid receptor antagonists in the treatment of patients with essential hypertension and resistant hypertension. METHOD: We conducted a meticulous review of the literature and comprehensive identification of the clinical trials assessing the efficacy of mineralocorticoid receptor antagonists in individuals with primary and resistant hypertension. RESULTS: MRAs have been thoroughly tested in several clinical studies in relevance to blood pressure lowering effects, over the last six decades. Accumulating data observed that MRAs resulted in a significant reduction in blood pressure level in patients with resistant hypertension. In addition, spironolactone was found to beneficially affect the management of resistant hypertension. CONCLUSION: Mineralocorticoid receptor antagonists exert a significant antihypertensive effect. Future welldesigned randomized controlled studies are greatly needed to address crucial clinical aspects in the field.
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Imprialos et al. (2019) conducted a review in Essential and resistant hypertension. Mineralocorticoid receptor antagonists was evaluated on Blood pressure reduction. Mineralocorticoid receptor antagonists, including spironolactone, resulted in a significant reduction in blood pressure levels in patients with resistant hypertension.
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