Key result
Age-related changes in preadipocyte gene expression differ among depots, with 8.4% of probe sets differing between depots and 0.02% with aging, potentially contributing to fat redistribution.
Population
Preadipocytes cultured from epididymal and perirenal depots of young, middle-aged, and old rats
Comparison
Aging and depot origin vs Young rats and epididymal depot
Design
Preclinical
Authors
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Rodent findings warrant no clinical change in fat management; leaves open human relevance of depot-specific preadipocyte aging.
Age-related changes in preadipocyte gene expression differ among fat depots, potentially contributing to fat redistribution and dysfunction.
Cartwright et al. (2010) studied Aging and fat distribution. Aging vs. Depot origin (epididymal vs perirenal) was evaluated on Gene expression differences in preadipocytes. Age-related changes in preadipocyte gene expression differ among depots, with 8.4% of probe sets differing between depots and 0.02% with aging, potentially contributing to fat redistribution.
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