Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

Anita S. Zot; John D. Potter

doi:10.1146/annurev.bb.16.060187.002535

June 1, 1987Annual Review of Biophysics and Biophysical Chemistry

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

View at Publisher

Ask AI

Bookmark

Share

Key Points

To review the structural organization and biochemical interactions of troponin subunits, tropomyosin, and actin in skeletal muscle regulation.
Structural and biochemical synthesis of skeletal muscle thin filament components.
Evaluation of subunit-level interactions among troponin C, troponin I, troponin T, tropomyosin, and actin.
Elucidation of direct interface contacts including tropomyosin-actin, TnT-tropomyosin, and TnC-TnI-actin binding networks.
Description of calcium-dependent structural transitions in troponin that alter tropomyosin positioning to govern actomyosin cross-bridge cycling.

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Narrative review uncovers the structural interactions governing troponin-tropomyosin regulation in skeletal muscle, highlighting molecular mechanisms of thin filament activation.

Abstract

PERSPECTIVES AND OVERVIEW . . . . . . . . . . . . ..... ... . . . . ... . . . . . . . . . . . . . . . . . . . .. . . . ... . . ... . . . . . . . . . . . . . . . . . . . . . ... . . . . . 535 THE THIN FILAMENT . ..... , .... , .... , ... .. ,., ,., .. .. ,', ... .. , ....... •.. .. 536 TROPONIN 537 Troponin C . . . ... . ..... . . . . . . ... ... . . . . . . . . . . . . . . . . ... . .... . . ... . . ........ . . ... . . . . . . ..... 537 Troponin ! ........ ... . . . .... . 543 Troponin T , 544 TROPOMYOSIN . . . ..... 545 INTERACTIONS OF REGULATORY PROTEINS . . . . . . . . ... . . ... . . . . . . . ... . ... . . . . . . . . . ...... 547 Tropomyosin-Actin ...... .... 547 TnT-Tropomyosin . ... . . ... . ... . . .... . ... . . ... . .... . ... . . ... . . .... . . . . . . ... . ......... . ... . .... . ... . .... . .... 548 TnT-TnC and TnT-Tn! 550 TnCTn! and Tn!-Actin . . . . . . . . ... 552 REGULATORY MECHANiSMS 553

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zot et al. (1987) studied this question.

synapsesocial.com/papers/6a156048a2352da347825747 https://doi.org/10.1146/annurev.bb.16.060187.002535

View at Publisher

Ask AI

Bookmark

Share

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Structural Aspects of Troponin-Tropomyosin Regulation of Skeletal Muscle Contraction

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading