This paper describes the foundational basic science discovery of troponin's role as the calcium-receptive regulatory protein in muscle contraction.
Defines sarcomeric Ca2+ regulation in HF models; leaves open isoform-specific therapeutic targeting.
The contraction-relaxation cycle of muscle under physiological conditions is regulated by the intracellular concentration of free Ca ion, which is under the control of the intracellular membraneous system, i.e., the sarcoplasmic reticulum (cf. Weber, 1966; Ebashi and Endo, 1968). The responsiveness to Ca ion requires the participation of a protein system in the interaction of myosin and actin (Ebashi, 1963). The protein system, first called "native tropomyosin " (Ebashi and Ebashi, 1964), consists of tropomyosin and a new protein, tropo-nin (Ebashi and Kodama, 1965), which is the real Ca-receptive protein (Ebashi et al., 1967, 1968; Yasui et al., 1968). In the absence of Ca ion, troponin in collaboration with tropomyosin exerts
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Ebashi et al. (1973) studied this question.
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