Key result
Genetically engineered Troponin C variants introduced into rabbit skeletal muscle fibers demonstrated that TnC regulates a step in the cross-bridge cycle beyond simple thin filament activation.
Population
single cell segments of chemically skinned skeletal rabbit psoas muscle fibres
Design
Preclinical
Authors
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Challenges simplistic TnC switch model; leaves open cardiac cross-bridge relevance in humans.
This study provides the first evidence that TnC regulates a step in the cross bridge cycle beyond thin filament activation showing that TnC is not just a simple switch.
Louise Ellen Leblanc (2009) studied this question. Genetically engineered Troponin C variants was evaluated on Tension, force development, and maximal rate of shortening. Genetically engineered Troponin C variants introduced into rabbit skeletal muscle fibers demonstrated that TnC regulates a step in the cross-bridge cycle beyond simple thin filament activation.
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