The study demonstrates that hepatic lipase in postheparin rat plasma hydrolyzes medium-chain triacylglycerols without positional specificity or inhibition by high sodium.
Rat hepatic lipase data extend TAG hydrolysis insights; leaves open human relevance and clinical translation.
Triacylglycerol lipase activity was studied using glycerol [1-13C]trioctanoate mixed with postheparin rat plasma. 13C NMR spectroscopy demonstrated triacylglycerol hydrolysis into free fatty acids with no difference at the 1,3 or 2 glycerol positions. There was no inhibition by high sodium concentration, consistent with lipase of hepatic origin.
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Dimand et al. (1989) studied this question.
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