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July 18, 2003The FASEB Journal

Inhibitors of hepatic microsomal triacylglycerol hydrolase decrease very low density lipoprotein secretion

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Why the study?

Does inhibition of triacylglycerol hydrolase decrease VLDL and apoB-100 secretion in primary rat hepatocytes?

Population

Primary rat hepatocytes and hepatoma cells transfected with triacylglycerol hydrolase cDNA

Comparison

Inhibition of triacylglycerol hydrolase vs Uninhibited state (control)

Design

Preclinical

Authors

DGDean GilhamResverlogix (Canada)SHSamuel B. HoBoston Biomedical (United States)MRMehdi RasouliUniversity of Alberta

Discussion

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Implication

Hypothesis-generating for TG hydrolase inhibition; leaves open translation to human lipid disorders.

Structured PICO

Does inhibition of triacylglycerol hydrolase decrease VLDL and apoB-100 secretion in primary rat hepatocytes?

P
Population
Primary rat hepatocytes and hepatoma cells transfected with triacylglycerol hydrolase cDNA
I
Intervention
Inhibition of triacylglycerol hydrolase (lipase activity)
C
Comparator
Uninhibited state (control)
O
Outcome
Secretion of triacylglycerols (TGs) and apolipoprotein B-100 (apoB-100)surrogate

Inhibition of intracellular triacylglycerol hydrolysis significantly decreases apoB-100 secretion, suggesting triacylglycerol hydrolase as a potential pharmacological target for lowering plasma lipids.

Cite This Study

Gilham et al. (2003) studied this question.

synapsesocial.com/papers/6a709cc6e5469ee92be1504chttps://doi.org/10.1096/fj.02-0728fje
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice1999 · 429 citations
  2. 2Influence of triacylglycerol biosynthesis rate on the assembly of apoB-100-containing lipoproteins in Hep G2 cells.1993 · 87 citations
  3. 3Regulation of hepatic secretion of apolipoprotein B-containing lipoproteins: information obtained from cultured liver cells.1993 · 368 citations
  4. 4The Activity of Microsomal Triglyceride Transfer Protein Is Essential for Accumulation of Triglyceride within Microsomes in McA-RH7777 Cells1999 · 129 citations
  5. 5Hepatic secretion of VLDL fatty acids during stimulated lipogenesis in men1998 · 137 citations