Key result
Maximum left atrial volume indexed to body surface area was independent of age and sex, producing a reference interval of 15-37 mL/m2 in subjects without apparent cardiovascular disease.
Cross-Sectional (n=168)
No
This study establishes normal reference ranges for maximum and minimum left atrial volumes in a healthy population, demonstrating that while maxLAVi is independent of age, minLAVi increases significantly with age.
The aim of the present study was to obtain reference values of maximum and minimum left atrial volumes (maxLAV and minLAV, respectively) in a population-based subset without apparent cardiovascular disease or other factors potentially associated with left atrial enlargement. Because left ventricular diastolic dysfunction is commonly found in elderly subjects, we also tried to identify the presence of possible preclinical diastolic dysfunction in the study population. A population-based sample of 168 subjects (127 men and 41 women) underwent two-dimensional echocardiography using the single-plane disc method to determine maxLAV and minLAV. maxLAV and minLAV were indexed to body surface area (maxLAVi and minLAVi, respectively). maxLAVi was independent of age and sex, and produced reference limits (mean ± 1.96 SD) of 15-37 mL/m(2). minLAVi was correlated with age, and produced estimated reference limits of 3-15 and 7-23 mL/m(2) in 40- and 80-year-old subjects, respectively. Based on the age-dependent reference values from the European Association of Cardiovascular Imaging, <5 % of the study population had possible preclinical left ventricular diastolic dysfunction. The present study established normal ranges for maxLAVi and minLAVi in a well-characterized population-based subset without apparent cardiovascular disease or other factors potentially associated with left atrial volume enlargement.
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Henriksen et al. (2014) conducted a cross-sectional in Without apparent cardiovascular disease (n=168). Echocardiography (single-plane disc method) was evaluated on Reference limits for maximum and minimum left atrial volumes indexed to body surface area (maxLAVi and minLAVi). Maximum left atrial volume indexed to body surface area was independent of age and sex, producing a reference interval of 15-37 mL/m2 in subjects without apparent cardiovascular disease.
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