Key result
Noninvasive 3-D cardiac electrical imaging correlated well with invasive intra-cardiac mapping (correlation coefficient 0.72, relative error 0.30) for localizing ventricular arrhythmias in rabbits.
Why the study?
Does noninvasive 3-D cardiac electrical imaging accurately localize the origins and image the activation sequence of focal ventricular arrhythmias compared to invasive mapping in a rabbit model?
Does noninvasive 3-D cardiac electrical imaging accurately localize the origins and image the activation sequence of focal ventricular arrhythmias compared to invasive mapping in a rabbit model?
Effect estimate: r 0.72
A novel 3-D cardiac electrical imaging technique is feasible for non-invasively localizing the origins and imaging the activation sequence of focal ventricular arrhythmias in a preclinical model.
Supports feasibility in rabbits; hypothesis-generating before human validation or clinical adoption.
Ventricular arrhythmias represent one of leading causes for sudden cardiac death, a significant problem in public health. Noninvasive imaging of cardiac electric activities associated with ventricular arrhythmias plays an important role in better our understanding of the mechanisms and optimizing the treatment options. The present study aims to rigorously validate a novel three-dimensional (3-D) cardiac electrical imaging (3-DCEI) technique with the aid of 3-D intra-cardiac mapping during paced rhythm and ventricular tachycardia (VT) in the rabbit heart. Body surface potentials and intramural bipolar electrical recordings were simultaneously measured in a closed-chest condition in thirteen healthy rabbits. Single-site pacing and dual-site pacing were performed from ventricular walls and septum. VTs and premature ventricular complexes (PVCs) were induced by intravenous norepinephrine (NE). The non-invasively imaged activation sequence correlated well with invasively measured counterparts, with a correlation coefficient of 0.72 and a relative error of 0.30 averaged over all paced beats and NE-induced PVCs and VT beats. The averaged distance from imaged site of initial activation to measured site determined from intra-cardiac mapping was ∼5mm. These promising results suggest that 3-DCEI is feasible to non-invasively localize the origins and image activation sequence of focal ventricular arrhythmias.
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Han et al. (2011) studied Ventricular arrhythmias (n=13). 3-D cardiac electrical imaging (3-DCEI) vs. 3-D intra-cardiac mapping was evaluated on Correlation of activation sequence between noninvasive imaging and invasive mapping (r 0.72). Noninvasive 3-D cardiac electrical imaging correlated well with invasive intra-cardiac mapping (correlation coefficient 0.72, relative error 0.30) for localizing ventricular arrhythmias in rabbits.
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