Key result
Presence of CT-assessed aortic valve calcification was not associated with the risk of all-cause dementia (HR 0.89; 95% CI 0.63-1.26).
Why the study?
Does the presence of aortic valve calcification increase the risk of dementia in non-demented individuals?
Cohort (n=2,428)
Does the presence of aortic valve calcification increase the risk of dementia in non-demented individuals?
CT-assessed aortic valve calcification is not associated with an increased risk of dementia or cognitive decline in a population-based cohort.
Aortic valve calcification warrants no dementia risk assessment; leaves open vascular-cognitive links in larger cohorts.
The association of aortic valve calcification (AVC) with dementia remains unknown. In 2,428 non-demented participants from the population-based Rotterdam Study, we investigated the association of CT-assessed AVC with risk of dementia and cognitive decline. AVC was present in 33.1% of the population. During a median follow-up of 9.3 years, 160 participants developed dementia. We found no association between presence of AVC and risk of all-cause dementia [hazard ratio (HR): 0.89 (95% confidence interval (CI):0.63;1.26)]. Presence of AVC was not associated with cognitive decline on any of the cognitive tests, nor with a measure of global cognition.
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Wolters et al. (2016) conducted a cohort in Aortic valve calcification (n=2,428). Aortic valve calcification (AVC) vs. Absence of AVC was evaluated on All-cause dementia (HR 0.89, 95% CI 0.63-1.26). Presence of CT-assessed aortic valve calcification was not associated with the risk of all-cause dementia (HR 0.89; 95% CI 0.63-1.26).
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