Key result
The 5-HTTLPR long allele and neuroticism/anxiety were associated with higher EEG-heart period correlations, indicating that individual differences in brain-heart covariation relate to 5-HT and anxiety.
Why the study?
Does the 5-HTTLPR polymorphism and anxiety modulate brain-heart covariation?
Cross-Sectional (n=168)
Does the 5-HTTLPR polymorphism and anxiety modulate brain-heart covariation?
The 5-HTTLPR polymorphism and anxiety levels are associated with individual differences in brain-heart covariation.
Answers are grounded in this paper and cite their sources.
Supports 5-HTTLPR-anxiety links to brain-heart covariation; hypothesis-generating and requires prospective validation.
To date, little is known about genes affecting the interplay of brain and heart activity. Because serotonin (5-HT) is involved in corticovagal neurotransmission, we tested whether the 5-HT transporter polymorphism 5-HTTLPR affects brain-heart covariation. Further, associations with neuroticism/anxiety (NANX) were tested, as anxiety is related to 5-HT and neurogenic changes of heart period (HP). N = 168 participants performed a time-estimation task while EEG and HP were recorded. Brain-heart covariation was measured using time-lagged within-subject correlations of centromedial feedback-evoked single-trial EEG at 300 ms and subsequent changes of HP. EEG-HP correlations were higher in 5-HTTLPR long allele carriers. Moreover, after negative feedback, EEG-HP correlations and feedback-related negativity amplitudes independently correlated with NANX. The results indicate that individual differences in brain-heart covariation relate to 5-HT and NANX.
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Mueller et al. (2013) reported a cross-sectional. 5-HTTLPR polymorphism and neuroticism/anxiety was evaluated on Brain-heart covariation measured using time-lagged within-subject correlations of centromedial feedback-evoked single-trial EEG at 300 ms and subsequent changes of heart period. The 5-HTTLPR long allele and neuroticism/anxiety were associated with higher EEG-heart period correlations, indicating that individual differences in brain-heart covariation relate to 5-HT and anxiety.
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