Key result
Higher central pulse pressure is linked to a greater number of damaged target organs.
Why the study?
It is not well known which components of central blood pressure are more influential to target organ damage in high-risk patients.
Does central pulse pressure correlate with target organ damage in high-risk patients with ASCVD or multiple risk factors?
Observational (n=148)
No
Does central pulse pressure correlate with target organ damage in high-risk patients with ASCVD or multiple risk factors?
p-value: p=0.010
Non-invasive measurement of central pulse pressure correlates strongly with multiple parameters of target organ damage and may be a useful indicator for cardiovascular risk stratification in high-risk patients.
Central pulse pressure may support risk stratification in high-risk ASCVD; leaves open incremental prognostic value in prospective studies.
Background It is not well-known which components of central blood pressure (CBP) are more influential to target organ damage (TOD). This study aimed to determine the relationship between CBP measurements and various types of TOD in high-risk patients. Methods A total of 148 patients who had documented atherosclerotic cardiovascular disease or its multiple risk factors were prospectively enrolled. CBP was measured by using applanation tonometry of the radial artery. The following nine TOD parameters were evaluated: left ventricular mass index, relative wall thickness, septal e′ velocity, septal E/e′, brachial-ankle pulse wave velocity, ankle-brachial index, estimated glomerular filtration rate, urine protein and obstructive coronary artery disease. Results The mean age of the study population was 67.1 ± 9.0 years and 108 (73 %) were male. Among four CBP measurements (systolic, diastolic, mean, and pulse pressures), central pulse pressure (CPP) was associated with the largest number of TOD parameters. As CPP increased, the number of TOD increased ( P = 0.010), but this association was not observed in other CBP measurements ( P > 0.05 for each). Conclusions CPP had a stronger correlation with TOD than other CBP measurements. Non-invasive CPP could be a useful indicator for predicting TOD in patients at high coronary risk.
No takes yet. Share an insight, caveat, or question.
Jeon et al. (2021) conducted an observational in Atherosclerotic cardiovascular disease or multiple risk factors (n=148). Central pulse pressure (CPP) vs. Other central blood pressure measurements was evaluated on Number of target organ damage parameters (p=0.010). Central pulse pressure was associated with the largest number of target organ damage parameters, with the number of damaged organs significantly increasing as central pulse pressure increased (P=0.010).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: