Key result
Chikungunya infection during pregnancy is not linked to increased pregnancy complications.
Why the study?
To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission among pregnant women with Chikungunya infection.
Does Chikungunya infection during pregnancy increase composite pregnancy complications and neonatal morbidity in pregnant women?
Observational (n=416)
Does Chikungunya infection during pregnancy increase composite pregnancy complications and neonatal morbidity in pregnant women?
This is the authors' abstract. We don't add key points for this paper.
OBJECTIVE: To evaluate pregnancy and neonatal outcomes, disease severity, and mother-to-child transmission of pregnant women with Chikungunya infection (CHIKV). DESIGN: Retrospective observational study. SETTING: Grenada. POPULATION: Women who gave birth during a Chikungunya outbreak between January 2014 and September 2015 were eligible. METHODS: This descriptive study investigated 731 mother-infant pairs who gave birth during a CHIKV outbreak. Women and infants underwent serological testing for CHIKV by ELISA. MAIN OUTCOME MEASURES: Primary outcomes: composite pregnancy complication (abruption, vaginal bleeding, preterm labour/cervical incompetence, cesarean delivery for fetal distress/abruption/placental abnormality or delivery for fetal distress) and composite neonatal morbidity. RESULTS: Of 416 mother-infant pairs, 150 (36%) had CHIKV during pregnancy, 135 (33%) had never had CHIKV, and 131 (31%) had CHIKV outside of pregnancy. Mean duration of joint pain was shorter among women infected during pregnancy (μ = 898 days, σ = 277 days) compared with infections outside of pregnancy (μ = 1064 days, σ = 244 days) (P < 0.0001). Rates of pregnancy complications (RR = 0.76, P = 0.599), intrapartum complications (RR = 1.50, P = 0.633), and neonatal outcomes were otherwise similar. Possible mother-to-child transmission occurred in two (1.3%) mother-infant pairs and two of eight intrapartum infections (25%). CONCLUSION: CHIKV infection during pregnancy may be protective against long-term joint pain sequelae that are often associated with acute CHIKV infection. Infection during pregnancy did not appear to pose a risk for pregnancy complications or neonatal health, but maternal infection just prior to delivery might have increased risk of mother-to-child transmission of CHIKV. TWEETABLE ABSTRACT: Chikungunya infection did not increase risk of pregnancy complications or adverse neonatal outcomes, unless infection was just prior to delivery.
Answers are grounded in this paper and cite their sources.
Chikungunya infection during pregnancy does not appear to increase the risk of pregnancy complications or adverse neonatal outcomes, though infection just prior to delivery may increase mother-to-child transmission risk.
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Foeller et al. (2020) conducted an observational in Chikungunya infection in pregnancy (n=416). Chikungunya infection during pregnancy vs. Never had Chikungunya or had infection outside of pregnancy was evaluated on Composite pregnancy complication and composite neonatal morbidity (RR 0.76, p=0.599). Chikungunya infection during pregnancy did not increase the risk of pregnancy complications compared to women who never had CHIKV or had it outside of pregnancy.
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