What question did this study set out to answer?

To evaluate 5-year cognitive and motor outcomes in infants with mild, moderate, and severe hypoxic ischemic encephalopathy (HIE) graded by early EEG and clinical assessment without therapeutic hypothermia.

September 20, 2016PEDIATRICS

Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy

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Authors

DMDeirdre M. MurrayUniversity College Cork COCatherine O’ConnorDundalk Institute of Technology CRC. Anthony RyanRoyal College of Surgeons in Ireland

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Implication

Cohort study reveals persistent cognitive deficits at 5 years in infants with mild neonatal hypoxic ischemic encephalopathy, indicating a need to re-evaluate treatment criteria.

Key Points

To evaluate 5-year cognitive and motor outcomes in infants with mild, moderate, and severe hypoxic ischemic encephalopathy (HIE) graded by early EEG and clinical assessment without therapeutic hypothermia.
Recruited term infants with HIE and healthy comparison controls at birth, recording continuous EEG within 6 hours of life.
Evaluated neurodevelopmental, cognitive, and motor outcomes at 5 years of age in infants untreated with therapeutic hypothermia (final follow-up: n=53 HIE, n=30 comparison controls).
Infants with mild HIE (n = 22) had significantly lower full-scale IQ (P = .001), verbal IQ (P = .001), and performance IQ (P = 0.004) at 5 years compared to healthy controls (n = 30).
No statistically significant difference in 5-year cognitive measures was detected between children with mild and moderate grades of HIE.
Intact survival at 5 years varied across 6-hour EEG grades: 75% for mild, 46% for moderate, 43% for major abnormalities, and 0% for inactive EEGs, compared to 97% in healthy comparison infants.

Cite This Study

Murray et al. (2016) studied this question.

synapsesocial.com/papers/6a15686ed64fa333899fa1f6 https://doi.org/10.1542/peds.2016-0659

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Implication

Cohort study reveals persistent cognitive deficits at 5 years in infants with mild neonatal hypoxic ischemic encephalopathy, indicating a need to re-evaluate treatment criteria.

Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Early EEG Grade and Outcome at 5 Years After Mild Neonatal Hypoxic Ischemic Encephalopathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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