Key result
The De-noised Jack-Knife neural network algorithm classified pediatric heart sounds as normal or pathological with a sensitivity of 92% and a specificity of 92.9%.
Why the study?
Does an automated artificial neural network based on electronic auscultation accurately discriminate between pathological and nonpathological heart sounds in pediatric patients?
Observational (n=163)
Yes
Does an automated artificial neural network based on electronic auscultation accurately discriminate between pathological and nonpathological heart sounds in pediatric patients?
Effect estimate: Sensitivity 92%, Specificity 92.9%
An automated artificial neural network can accurately discriminate between pathological and nonpathological heart sounds in pediatric patients, offering a potential screening tool for resource-limited settings.
May support automated pediatric screening in resource-limited settings; leaves open prospective validation before clinical adoption.
Most of the relevant and severe congenital cardiac malfunctions can be recognized in the neonatal period of a child's life. Misclassification of a congenital heart defect may have serious consequences on the long-term outcome of the affected child. Experienced cardiologists can usually evaluate heart murmurs with secure confidence, whereas nonspecialists, with less clinical experience, may have more difficulty. There is an acute shortage of physicians in South Africa and many rural clinics are run by nurses. Automated screening based on electronic auscultation at clinic level could therefore be of great benefit. This paper describes an automated artificial neural network as well as a direct ratio and a wavelet analysis technique, to discriminate between pathological and nonpathological heart sounds. To test the performance of the three techniques, auscultation data and electrocardiogram (ECG)-data of 163 patients, aged between 2 mo and 16 yr, were digitized. The neural network achieved a sensitivity and specificity of 90% and 96.5%, respectively, when tested with the Jack-knife method. Statistical analysis of the input to the final sigmoid function shows that a better than 99% sensitivity and specificity can be achieved if sufficient training data are available.
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Vos et al. (2007) conducted an observational in Pediatric heart murmurs (n=163). De-noised Jack-Knife neural network algorithm was evaluated on Classification of heart sounds into normal and pathological classes (Sensitivity 92%, Specificity 92.9%). The De-noised Jack-Knife neural network algorithm classified pediatric heart sounds as normal or pathological with a sensitivity of 92% and a specificity of 92.9%.
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