A novel 40-ml stroke volume paraaortic blood pump significantly improved classical counterpulsation indices by 1.5-3.5 times compared to a standard intraaortic balloon pump (p≤0.05).
RCT (n=8)
randomly divided
Does a novel paraaortic blood pump improve acute hemodynamic and metabolic indices compared to a standard intraaortic balloon pump in an acute porcine model?
In an acute porcine model, a novel paraaortic blood pump provided superior hemodynamic and metabolic support compared to a standard intraaortic balloon pump.
Estimación del efecto: 1.5-3.5 times greater
valor p: p=≤0.05
Despite the success of intraaortic balloon counterpulsation, data on physiologic indices and optimal inflation/deflation timing control of chronic counterpulsation devices are unclear. This study explored the acute hemodynamic and metabolic efficacy of a novel 40-ml stroke volume paraaortic blood pump (PABP) versus a standard intraaortic balloon pump (IABP). Acute porcine model was used with eight pigs randomly divided into PABP (n = 4) and IABP (n = 4) groups. Hemodynamic and metabolic measurements were obtained with and without mechanical assistance. In one pig, the inflation/deflation control was adjusted to different settings, with corresponding performance indices measured. The PABP significantly improved classical counterpulsation indices (p ≤ 0.05) and achieved an average beneficial effect on these indices 1.5-3.5 times greater than that of the IABP. Classical metabolic indices (tension time index and endocardial viability ratio EVR), and indices new to chronic counterpulsation research (coronary perfusion, left ventricular stroke work (SW), and a newly derived EVR) were also used in assessment. Both IABP assistance and PABP assistance improved these physiologic indices, with a trend toward PABP superiority in reducing left ventricular SW (p = 0.08). An optimal PABP deflation timing occurs during systole (25 milliseconds after the R-wave) and can minimize coronary regurgitation.
Lu et al. (Thu,) conducted a rct in Acute hemodynamic and metabolic efficacy (n=8). paraaortic blood pump (PABP) vs. intraaortic balloon pump (IABP) was evaluated on classical counterpulsation indices (1.5-3.5 times greater, p=≤0.05). A novel 40-ml stroke volume paraaortic blood pump significantly improved classical counterpulsation indices by 1.5-3.5 times compared to a standard intraaortic balloon pump (p≤0.05).