Key result
Acetylsalicylic acid treatment for primary prevention of cardiovascular diseases has an undefined balance of benefits and risks, but appears unfavorable in many older patients.
Why the study?
Does acetylsalicylic acid therapy provide a favorable balance of benefits and risks for primary prevention of cardiovascular diseases in older patients with diabetes?
Does acetylsalicylic acid therapy provide a favorable balance of benefits and risks for primary prevention of cardiovascular diseases in older patients with diabetes?
In older patients with diabetes, the balance of benefits and risks for primary prevention with aspirin is not well defined, but it appears unfavorable for many older patients.
Aspirin primary prevention warrants caution in older diabetics due to unfavorable risk-benefit; leaves open need for targeted RCTs in this subgroup.
Cardiovascular diseases (CVDs) represent a huge health burden for older patients with diabetes. Acetylsalicylic acid (ASA) has long been used as a cardioprotective agent in primary and secondary prevention of CVD. However, there are important issues regarding the benefits and risks of ASA therapy in primary prevention of CVDs, for the older group in general and for individuals of all ages with diabetes. In this review, we summarize the benefits and risks related to ASA therapy by outlining the evidence for older patients and for patients with diabetes. There appear to be significant gaps in knowledge. The balance of benefits and risks is not well defined but ASA treatment seems to be unfavorable in many older patients.
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Sirois et al. (2012) conducted a review in Cardiovascular diseases in older patients with diabetes. Acetylsalicylic acid (ASA) was evaluated. Acetylsalicylic acid treatment for primary prevention of cardiovascular diseases has an undefined balance of benefits and risks, but appears unfavorable in many older patients.
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