Key result
Acetylsalicylic acid for primary prevention decreased serious vascular events but increased bleeding and hemorrhagic stroke in a meta-analysis of six randomized studies.
Why the study?
Recent studies have raised key questions regarding the benefits and risks of using acetylsalicylic acid for the primary prevention of cardiovascular death.
Does acetylsalicylic acid prevent cardiovascular death in patients for primary prevention of cardiovascular diseases?
Meta-Analysis
Does acetylsalicylic acid prevent cardiovascular death in patients for primary prevention of cardiovascular diseases?
The abstract highlights the ongoing debate regarding the benefits and bleeding risks of acetylsalicylic acid for primary prevention of cardiovascular disease.
Ongoing debate on acetylsalicylic acid primary prevention warrants caution; leaves open optimal risk-benefit balance for trials.
Numerous studies have investigated use of acetylsalicylic acid (ASA) for prevention of cardiovascular deaths. The vast majority of the work in this area has focused on secondary prevention. However, underuse of ASA still remains a major issue. Fewer studies have investigated the impact of ASA on primary prevention of cardiovascular death. A meta-analysis of individual participant data from six randomized studies, published in 2009, showed decrease in serious vascular events but at the cost of causing increased bleeding and hemorrhagic stroke. Recent studies have raised a number of key questions regarding the benefits and risks of using ASA for primary prevention.
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Upadhaya et al. (2018) conducted a meta-analysis in Primary prevention of cardiovascular diseases. Acetylsalicylic acid (ASA) was evaluated on Serious vascular events, bleeding, and hemorrhagic stroke. Acetylsalicylic acid for primary prevention decreased serious vascular events but increased bleeding and hemorrhagic stroke in a meta-analysis of six randomized studies.
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