Key result
The use of acetylsalicylic acid for primary prevention of cardiovascular diseases remains debated, though it may reduce CVD incidence in patients aged 40-70 with high cardiovascular and low bleeding risk.
Why the study?
While acetylsalicylic acid is effective for secondary prevention of cardiovascular diseases, its use for primary prevention remains debated due to inconsistent study results.
Does acetylsalicylic acid (ASA) reduce the incidence of cardiovascular diseases when used for primary prevention in patients with high or medium risk of CVD?
Does acetylsalicylic acid (ASA) reduce the incidence of cardiovascular diseases when used for primary prevention in patients with high or medium risk of CVD?
The role of aspirin in the primary prevention of cardiovascular disease remains controversial, with potential benefits likely limited to specific high-risk populations with low bleeding risk.
Answers are grounded in this paper and cite their sources.
Should not change primary prevention practice; leaves open targeted trials in select 40-70-year-olds with high CVD and low bleeding risk.
Chronic noninfectious diseases (cardiovascular, bronchopulmonary, oncological diseases and diabetes mellitus) are presently the most common cause of death worldwide, with cardiovascular diseases (CVD) being predominant. For this reason, the key goal of a physician is not only to treat but also to prevent diseases. Acetylsalicylic acid (ASA) is considered one of the most effective drugs for secondary prevention of CVD. However, the use of ASA for primary prevention is still debated. Results of many studies of ASA are inconsistent. Some studies have suggested that using ASA in patients aged 40-70 with a high 10-year risk of CVD and a low risk of bleeding may reduce the incidence of CVD. Administration of ASA to patients with a high or medium risk of CVD is also considered.
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Ларина et al. (2020) conducted a review in Cardiovascular diseases. Acetylsalicylic acid (ASA) was evaluated. The use of acetylsalicylic acid for primary prevention of cardiovascular diseases remains debated, though it may reduce CVD incidence in patients aged 40-70 with high cardiovascular and low bleeding risk.
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