Key result
Surgical mitral plasticity for chronic ischemic MR is linked to 0% recurrence of moderate-to-severe MR.
Why the study?
Mitral valve repair for chronic ischemic mitral regurgitation has suboptimal outcomes due to high recurrence rates, prompting evaluation of whether augmenting the anterior leaflet and cutting second-order chords with restrictive annuloplasty improves midterm results.
Does surgical mitral plasticity improve ejection fraction and prevent recurrence of moderate or severe mitral regurgitation in patients with chronic ischemic mitral regurgitation?
Observational (n=22)
Does surgical mitral plasticity improve ejection fraction and prevent recurrence of moderate or severe mitral regurgitation in patients with chronic ischemic mitral regurgitation?
Surgical mitral plasticity (anterior leaflet augmentation, chord cutting, and annuloplasty) safely improved ejection fraction and prevented recurrence of significant mitral regurgitation at 1 year in a small cohort with chronic ischemic mitral regurgitation.
Hypothesis-generating in chronic ischemic MR; larger prospective trials needed before clinical adoption.
BACKGROUND AND AIM OF THE STUDY: The outcome of mitral valve (MV) repair for chronic ischemic mitral regurgitation (IMR) is suboptimal, due to the high recurrence rate of moderate or severe mitral regurgitation (MR) during follow-up. The MV adapts to new MR increasing its area to cover the enlarged annular area (mitral plasticity). As this process is often incomplete, we aimed to evaluate if augmenting the anterior leaflet (AL) and cutting the second-order chords (CC) together with restrictive mitral annuloplasty, a strategy we call "surgical mitral plasticity," could improve the midterm results of MV repair for IMR. MATERIALS AND METHODS: From November 2017 to October 2019, 22 patients with chronic IMR underwent surgical mitral plasticity. Mean age was 73 ± 7 years and six were female. Mean ejection fraction was 32% ± 11%, IMR grade was moderate in 10 and severe in 12. Mean clinical and echocardiographic follow-up was 12 ± 6 months. RESULTS: There was no early death, and one patient died 6 months after surgery. Ejection fraction improved from 32% ± 15% to 40% ± 6% (P = .031). IMR was absent or mild in all patients, and none showed recurrent moderate or more IMR. Tenting area decreased significantly from 2.5 ± 0.5 to 0.5 ± 0.3 cm² and coaptation length increased from 1.9 ± 0.7 to 7.8 ± 1.6 mm. All patients were in New York Heart Association class I or II. CONCLUSIONS: Mitral plasticity, if uncomplete, is ineffective in preventing IMR to become significant. Surgical mitral plasticity, by completing incomplete process of MV adaptation, has a strong rationale, which however needs to be validated with longer follow-up.
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Calafiore et al. (2020) conducted an observational in Chronic ischemic mitral regurgitation (n=22). Surgical mitral plasticity (augmenting anterior leaflet, cutting second-order chords, and restrictive mitral annuloplasty) was evaluated on Recurrent moderate or severe mitral regurgitation. Surgical mitral plasticity in patients with chronic ischemic mitral regurgitation improved mean ejection fraction from 32% to 40% (P=0.031) with 0% recurrence of moderate or severe MR.
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