What does this research mean for the field?

T-type calcium channels play a critical role in mediating stimulus-secretion coupling for aldosterone secretion in response to high extracellular potassium and angiotensin II in adrenal glomerulosa cells. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

April 1, 1988Proceedings of the National Academy of SciencesOpen Access

Ca channels in adrenal glomerulosa cells: K+ and angiotensin II increase T-type Ca channel current.

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Population

Freshly dispersed bovine adrenal glomerulosa cells

Design

Preclinical

Authors

CCCharles J. CohenXenon Pharmaceuticals (Canada)RMR. T. McCarthyYale University PBPaula Q. BarrettUniversity of Virginia

Discussion

Member takes

Implication

Does not alter clinical aldosterone management; leaves open T-type Ca channel targeting for human validation.

Structured PICO

Population

Freshly dispersed bovine adrenal glomerulosa cells

Intervention

Extracellular K+ concentration (Ko) and angiotensin II (AII)

Outcome

Ca channel currents (T-type and L-type) and aldosterone secretionsurrogate

T-type calcium channels play a crucial role in mediating aldosterone secretion in response to high potassium or angiotensin II in bovine adrenal glomerulosa cells.

Cite This Study

Cohen et al. (1988) studied this question.

synapsesocial.com/papers/6a156b3f814bf8ec9a4e9065 https://doi.org/10.1073/pnas.85.7.2412

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Ca channels in adrenal glomerulosa cells: K+ and angiotensin II increase T-type Ca channel current.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Ca channels in adrenal glomerulosa cells: K+ and angiotensin II increase T-type Ca channel current.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider