Why the study?
Does sustained oral isosorbide dinitrate therapy induce tolerance to its circulatory effects in patients with chronic stable angina, and is this tolerance reversible?
Population
10 patients with chronic, stable angina
Comparison
15 mg of isosorbide dinitrate orally every 6… vs Control stage and a 48-hour period where…
Design
Cohort
Follow-up
96 hours (48 hours therapy + 48 hours placebo substitution)
Authors
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Sustained isosorbide dinitrate may induce tolerance in stable angina; supports rapid reversibility but leaves optimal regimens open for randomized trials.
Does sustained oral isosorbide dinitrate therapy induce tolerance to its circulatory effects in patients with chronic stable angina, and is this tolerance reversible?
Sustained therapy with oral isosorbide dinitrate rapidly induces tolerance to its hemodynamic effects, which is quickly reversed upon discontinuation and is unlikely to be caused by altered pharmacokinetics.
Parker et al. (1983) studied this question.
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