Key result
Higher platelet distribution width and mean platelet volume are linked to acute ischemic stroke and severity.
Why the study?
Larger platelets are markers of increased platelet activity and prothrombotic potential, prompting examination of the relationship between platelet indices and stroke severity and outcome.
Are platelet indices associated with the occurrence and severity of acute ischemic stroke in non-diabetic, non-hypertensive patients?
Case-Control (n=210)
No
Are platelet indices associated with the occurrence and severity of acute ischemic stroke in non-diabetic, non-hypertensive patients?
Absolute Event Rate: 17.53% vs 15.47%
Higher platelet distribution width and mean platelet volume are associated with the occurrence and severity of acute ischemic stroke in non-diabetic, non-hypertensive patients.
Platelet indices may aid severity assessment in this population; hypothesis-generating and should not yet change practice.
BACKGROUND Platelet size, measured as mean platelet volume (MPV), is a marker of platelet function and is positively associated with indicators of platelet activity, including aggregation and release of thromboxane A2, platelet factor 4, and thromboglobulin.1 Larger platelets are metabolically more active, produce more prothrombotic factors, aggregate more easily & act as index of homeostasis and its dysfunction thrombosis.2 The purpose of this study was to examine the relationship between platelet indices and stroke, as well as its severity and outcome. METHODS This was a prospective observational case control study. This study was conducted with 105 non-diabetic, non-hypertensive ischemic stroke patients who had no history of previous thrombotic events and who had not previously taken any antiplatelet medications. These patients were examined within 24 hours of onset of symptoms and severity of stroke was calculated by Canadian neurological scale (CNS). The results were compared with 105 age and sex match controls. RESULTS Mean age of patients was 61.72 ± 12 and of controls was 62.85 ± 10.68. Based on the CNS score, participants were allocated into two groups; the first group were those who had a comprehension deficit (1st group, 43 patients) and the second group were those without a comprehension deficit (2nd group, 62 patients). Mean values for platelet distribution width (PDW) & MPV in 1st group was 18.329 and 12.55 respectively and in 2nd group was 16.98 and 11.48 respectively. The mean value of PDW and MPV for stroke patients was 17.53 ± 0.76 and 11.92 ± 0.58 and was significantly higher than mean value of PDW & MPV respectively in controls, which were 15.47 ± 0.26 and 10.43 ± 0.23. PDW & MPV was found to be significantly associated with severity of motor deficit. CONCLUSIONS Larger studies may be required to determine its utility in day-to-day clinical practice. However, platelet indices can be used for predicting the severity of deficit in patients of acute ischemic stroke.
No takes yet. Share an insight, caveat, or question.
N.K. et al. (2021) conducted a case-control in Acute Ischemic Stroke (n=210). Platelet indices (PDW and MPV) vs. Age and sex matched controls was evaluated on Mean platelet distribution width (PDW). Platelet distribution width (17.53 vs 15.47) and mean platelet volume (11.92 vs 10.43) were significantly higher in acute ischemic stroke patients compared to controls and associated with severity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: