Key result
High sensitive C-reactive protein was elevated in 90% of patients with acute coronary artery disease and showed a statistically significant correlation with CPK-MB and troponin-T (P<0.05).
Why the study?
Does high sensitive C-reactive protein (HS-CRP) correlate with cardiac markers in patients with acute coronary artery disease?
Observational (n=100)
Does high sensitive C-reactive protein (HS-CRP) correlate with cardiac markers in patients with acute coronary artery disease?
p-value: p=< 0.05
HS-CRP correlates significantly with established cardiac markers (troponin-T, CPK-MB) in acute CAD, suggesting its potential utility as an adjunctive diagnostic marker.
Supports adjunctive diagnostic role for HS-CRP in acute CAD; leaves open prospective validation before clinical adoption.
Introduction: High sensitive C-reactive protein (HS-CRP) is very sensitive acute phase reactant of inflammation. It is hypothesized that a relationship exists between HS-CRP and acute coronary artery disease (CAD). Materials and Methods: Consecutive sampling of 100 patients were done who presented with acute attack of CAD. In all these patients, Serum analysis for cardiac markers such as troponin-T and creatine phosphokinase-MB (CPK-MB) and serum analysis for quantitative estimation of HS-CRP were done along with few other parameters. Results: In our study, HS-CRP was raised in 90% of patients, along with CPK-MB and troponin-T and as an acute phase reactant, it showed parallel rise in total leukocyte count and absolute neutrophil count. The correlation scatter graphs were plotted, which were found to be statistically significant, (P < 0.05). Conclusion: HS-CRP as an acute phase reactant correlates with other acute phase reactants such as total leukocyte count and absolute neutrophil count and also the rise in HS-CRP value in patients of acute CAD correlates with CPK-MB and troponin-T, so that it can be used as a marker for diagnostic purpose in these patients.
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Shrivastav et al. (2015) conducted an observational in Acute coronary artery disease (CAD) (n=100). High sensitive C-reactive protein (HS-CRP) vs. Troponin-T and CPK-MB was evaluated on Correlation of HS-CRP with cardiac markers (troponin-T and CPK-MB) (p=< 0.05). High sensitive C-reactive protein was elevated in 90% of patients with acute coronary artery disease and showed a statistically significant correlation with CPK-MB and troponin-T (P<0.05).
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