Key result
Men in the highest quartile of serum homocysteine levels had a 2.9-fold increased adjusted risk of dying from ischemic heart disease compared to the lowest quartile (95% CI 1.8-4.7).
Why the study?
Do higher serum homocysteine levels increase the risk of death from ischemic heart disease in men?
Population
229 men without a history of ischemic heart disease at study entry who subsequently died of IHD and 1126…
Comparison
Higher serum homocysteine levels vs Lower serum homocysteine levels (lowest quartile)
Design
Case-control
Authors
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Should not change practice; leaves open whether homocysteine lowering reduces ischemic heart disease mortality.
Case-Control (n=1,355)
Do higher serum homocysteine levels increase the risk of death from ischemic heart disease in men?
Effect estimate: RR 2.9 (95% CI 1.8-4.7)
p-value: p=<.001
Elevated serum homocysteine levels are strongly and independently associated with an increased risk of death from ischemic heart disease, supporting a potential causal role.
Wald et al. (1998) conducted a case-control in Ischemic heart disease (n=1,355). Serum homocysteine vs. Lowest quartile of serum homocysteine was evaluated on Death from ischemic heart disease (RR 2.9, 95% CI 1.8-4.7, p=<.001). Men in the highest quartile of serum homocysteine levels had a 2.9-fold increased adjusted risk of dying from ischemic heart disease compared to the lowest quartile (95% CI 1.8-4.7).
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