Why the study?
Does VEGFR inhibition with SU5416 combined with chronic hypoxia induce severe pulmonary arterial hypertension pathology in mice compared to hypoxia alone?
Does VEGFR inhibition with SU5416 combined with chronic hypoxia induce severe pulmonary arterial hypertension pathology in mice compared to hypoxia alone?
The combination of SU5416 and chronic hypoxia establishes a novel murine model that closely mimics severe human pulmonary arterial hypertension.
No immediate clinical implications; extends murine models available for severe PAH research.
No abstract yet. The journal hasn't published one we can show.
No takes yet. Share an insight, caveat, or question.
Ciuclan et al. (2011) studied Severe pulmonary arterial hypertension. SU5416 combined with chronic hypoxia vs. Hypoxia alone was evaluated on PAH pathology development (hemodynamics, cardiac function, histological assessment).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:
More on EchocardiographyMore from American Journal of Respiratory and Critical Care Medicine