What does this research mean for the field?

The drop in resting potential of mammalian heart preparations during severe hypothermia is caused by a decrease in the active extrusion of sodium ions, contradicting hypotheses based on extracellular potassium accumulation or increased inward sodium current. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

May 1, 1960Circulation ResearchOpen Access

Possible Reasons for Drop of Resting Potential of Mammalian Heart Preparations During Hypothermia

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Population

Sheep ventricular and Purkinje fibers

Comparison

Hypothermia and various experimental conditions vs Baseline/normal temperature and theoretical…

Design

Preclinical

Authors

JDJ. DélèzeUniversité de Poitiers

Discussion

Member takes

Implication

Hypothermia may exaggerate cardiac resting potential loss beyond concentration theory in mammals; leaves open human relevance and clinical translation.

Structured PICO

Population

Sheep ventricular and Purkinje fibers

Intervention

Hypothermia (cooling from 37 to 0 C) and various experimental conditions (rapid heating, Na-free solution, poisoning)

Comparator

Baseline/normal temperature (37 C) and theoretical concentration potential predictions

Outcome

Resting potential changessurrogate

The study provides early electrophysiological evidence that active sodium extrusion contributes to the resting membrane potential in mammalian cardiac fibers, which is inhibited by hypothermia.

Cite This Study

J. Délèze (1960) studied this question.

synapsesocial.com/papers/6a156fd99b87f33fc69f8e04 https://doi.org/10.1161/01.res.8.3.553

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May 1, 1960Circulation ResearchOpen Access

Possible Reasons for Drop of Resting Potential of Mammalian Heart Preparations During Hypothermia

View Full Paper

Ask AI

Bookmark

Population

Sheep ventricular and Purkinje fibers

Comparison

Hypothermia and various experimental conditions vs Baseline/normal temperature and theoretical…

Design

Preclinical

Authors

JDJ. DélèzeUniversité de Poitiers

Discussion

Member takes

Implication

Hypothermia may exaggerate cardiac resting potential loss beyond concentration theory in mammals; leaves open human relevance and clinical translation.

Structured PICO

Population

Sheep ventricular and Purkinje fibers

Intervention

Hypothermia (cooling from 37 to 0 C) and various experimental conditions (rapid heating, Na-free solution, poisoning)

Comparator

Baseline/normal temperature (37 C) and theoretical concentration potential predictions

Outcome

Resting potential changessurrogate

The study provides early electrophysiological evidence that active sodium extrusion contributes to the resting membrane potential in mammalian cardiac fibers, which is inhibited by hypothermia.

Cite This Study

J. Délèze (1960) studied this question.

synapsesocial.com/papers/6a156fd99b87f33fc69f8e04 https://doi.org/10.1161/01.res.8.3.553

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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