Key result
Smoking showed a non-significant trend toward lower microvascular endothelial function as measured by acetylcholine-induced vasodilation compared to non-smokers (p=0.16).
Why the study?
The study was conducted to understand the role of smoking in influencing endothelial function as assessed by laser Doppler flowmeter among non-smoker and smoker males.
Does tobacco smoking reduce microvascular endothelial function in healthy young males?
Observational (n=51)
No
Does tobacco smoking reduce microvascular endothelial function in healthy young males?
In young, healthy males with a light smoking history, microvascular endothelial function assessed by laser Doppler flowmetry was lower than in non-smokers, though the difference did not reach statistical significance.
No practice change indicated for young males; leaves open whether light smoking impairs microvascular endothelial function.
Background: To understand the role of smoking in influencing endothelial function as assessed by LDF among non-smoker and smoker males. Methods: The LDF measurement for a total of 35 non-smokers and 16 smokers was done in the central research laboratory after written informed consent. The change in LDF signal in response to acetylcholine 100 µl, which was delivered to the forearm skin by iontophoresis, was measured as perfusion units (PU). Results: The pre-ACh LDF signal were statistically not significant between the groups. The increase in LDF signal was more prominent in non-smoker group. The LDF signal parameters such as differences in minimal response pre and post-ACh; difference in mean response pre and post ACh; the difference in maximal response pre and post ACh was not statistically significant between groups. However, the difference in the area under curve (AUC) pre and post-ACh (PU.min) (non-smoker 20089.34 (3438.92) vs smoker 13220.72 (3379.52); p=0.16) showed a trend towards statistical significance. Conclusions: Microvascular endothelial function as assessed by LDF signal among smokers (pack-years;1.9±1.44) and non-smokers is statistically insignificant. However, lower microvascular endothelial function is observed among smokers.
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Srinivasamurthy et al. (2023) conducted an observational in Healthy (n=51). Smoking vs. Non-smokers was evaluated on Difference in AUC pre and post-ACh (PU.min) (p=0.16). Smoking showed a non-significant trend toward lower microvascular endothelial function as measured by acetylcholine-induced vasodilation compared to non-smokers (p=0.16).
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