Current smoking was associated with a greater vasoconstrictor response to acetylcholine over 6 months compared to nonsmokers (-21.7% vs -8.3%).
Cohort (n=54)
Does smoking status influence the progression of coronary endothelial dysfunction in normotensive patients with coronary artery disease?
Continued smoking is associated with a marked decline in endothelium-dependent vasomotor response over 6 months in patients with coronary artery disease.
Tasa de eventos absoluta: -21.7% vs -8.3%
BACKGROUND: Cigarette smoking is a major risk factor for developing coronary artery disease and is associated with increased coronary morbidity and mortality in patients with established atherosclerosis. This report describes the influence of smoking on coronary endothelial function in normotensive patients with coronary artery disease, but without left ventricular dysfunction, severe hypercholesterolemia, or insulin-dependent diabetes mellitus. METHODS: Placebo-treated patients (n = 54) from a larger study assessing coronary endothelial function were classified at baseline as smokers or nonsmokers for this subgroup analysis. Patients underwent coronary angiography at baseline and again after 6-month follow-up. RESULTS: At baseline, there was a trend for a greater decrease in target segment diameter (n = 54) in smokers compared with nonsmokers (-17.2 +/- 5.3% vs. -8.0 +/- 2.5%, acetylcholine 10(-4) mol/l). All measured coronary artery segments (n = 202) showed similar responses (-7.3 +/- 2.7% vs. -3.8 +/- 1.3%, acetylcholine 10(-4) mmol/l, for smokers vs. nonsmokers, respectively). After 6 months, smokers showed an even greater vasoconstrictor response to acetylcholine whereas nonsmokers did not (-21.7 +/- 5.3% vs. -8.3 +/- 2.5%, acetylcholine 10(-4) mmol/l). The vasodilatory response to nitroglycerin was similar in smokers and nonsmokers. CONCLUSIONS: In current smokers, a marked decline in endothelium-dependent vasomotor response was observed over a 6-month period.
Pepine et al. (Fri,) conducted a cohort in coronary artery disease (n=54). Smoking vs. Nonsmokers was evaluated on Vasoconstrictor response to acetylcholine (change in target segment diameter) at 6 months. Current smoking was associated with a greater vasoconstrictor response to acetylcholine over 6 months compared to nonsmokers (-21.7% vs -8.3%).