Why the study?
Does vitamin C administration improve coronary flow reserve in smokers without coronary disease?
Population
n=19 subjects (11 smokers without coronary disease and 8 control subjects)
Comparison
Vitamin C administration vs Control subjects and baseline measurements
Design
Other
Authors
Discussion
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Implication
Vitamin C may acutely restore coronary flow reserve in smokers; hypothesis-generating for antioxidant effects on microvascular function, pending larger trials.
Structured PICO
Does vitamin C administration improve coronary flow reserve in smokers without coronary disease?
P
Population
n=19 subjects (11 smokers without coronary disease and 8 control subjects)
I
Intervention
Vitamin C administration
C
Comparator
Control subjects and baseline measurements (before vitamin C administration)
O
Outcome
Coronary flow reserve measured by positron emission tomographysurrogate
Vitamin C restores impaired coronary microcirculatory responsiveness and coronary flow reserve in smokers, demonstrating that smoking-induced coronary dysfunction is partly driven by oxidative stress.
Cite This Study
Kaufmann et al. (2000) studied this question.