Key result
Tobacco consumption was associated with significant differences in approximately one-half of measured serum cardiovascular biomarkers, with IL-12(p70), sICAM-1, and IL-8 best differentiating groups.
Why the study?
Does tobacco consumption (cigarette smoking or moist snuff) alter cardiovascular biomarkers of biological effect compared to non-tobacco consumption in healthy adult males?
Cross-Sectional
Does tobacco consumption (cigarette smoking or moist snuff) alter cardiovascular biomarkers of biological effect compared to non-tobacco consumption in healthy adult males?
Cigarette smoking and moist snuff consumption are associated with distinct profiles of cardiovascular biomarkers of biological effect compared to non-tobacco use.
Tobacco-associated biomarker differences should not yet change practice; hypothesis-generating for longitudinal outcome studies.
An age-stratified, cross-sectional study was conducted in the US among healthy adult male cigarette smokers, moist snuff consumers, and non-tobacco consumers to evaluate cardiovascular biomarkers of biological effect (BoBE). Physiological assessments included flow-mediated dilation, ankle-brachial index, carotid intima-media thickness and expired carbon monoxide. Approximately one-half of the measured serum BoBE showed statistically significant differences; IL-12(p70), sICAM-1 and IL-8 were the BoBE that best differentiated among the three groups. A significant difference in ABI was observed between the cigarette smokers and non-tobacco consumer groups. Significant group and age effect differences in select biomarkers were identified.
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Nordskog et al. (2015) conducted a cross-sectional in Healthy. Tobacco consumption (cigarette smoking, moist snuff) vs. Non-tobacco consumers was evaluated on Cardiovascular biomarkers of biological effect (BoBE). Tobacco consumption was associated with significant differences in approximately one-half of measured serum cardiovascular biomarkers, with IL-12(p70), sICAM-1, and IL-8 best differentiating groups.
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