Key result
Esophageal motility disorders affect ~61% of Type 2 diabetics and link to autonomic dysfunction.
Why the study?
Little attention has been given to esophageal disorders in diabetes mellitus, and the relationship between esophageal motility disorders and autonomic neuropathy remains to be clarified.
Cross-Sectional (n=38)
p-value: p=0.002
Esophageal motility disorders are highly prevalent in Type 2 diabetes and are significantly associated with autonomic nervous system dysfunction, particularly parasympathetic impairment.
May warrant esophageal evaluation in symptomatic T2DM with autonomic neuropathy; hypothesis-generating and requires prospective confirmation.
Little attention has been given to esophageal disorders in diabetes mellitus. Pathophysiology of esophageal motility disorders (EMD) in patients with diabetes mellitus is multifactorial. The aims of the present study were: (a) to evaluate the prevalence of EMD in patients with Type 2 diabetes mellitus and (b) to determine the relationship between EMD and autonomic neuropathy as assessed by heart rate variability (HRV). All the patients completed a questionnaire about diabetes characteristics and gastrointestinal symptoms. Conventional esophageal manometry was performed in all patients. HRV was measured in three different situations (Lying Position 1, standing position, and Lying Position 2). The temporal and frequency domain parameters were considered for analysis. The prevalence of EMD in our patients was 60.5% ( n = 23). Low score physical activity was significantly more frequent in patients with EMD ( p = .03). There was an increase in sympathetic activity represented by the low frequency (LF) parameter ( p = .027) in the presence of EMD. Whereas parasympathetic modulation of heart rate represented by the high frequency (HF) parameter ( p = .027) was declined in patients with EMD compared to those without. The LF/HF ratio was significantly higher ( p = .002) in patients with EMD. EMD were prevalent in diabetes mellitus and were associated to autonomic nervous system dysfunction predominantly at the parasympathetic component.
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Gallas et al. (2022) conducted a cross-sectional in Type 2 diabetes mellitus (n=38). Esophageal motility disorders (EMD) vs. No EMD was evaluated on Prevalence of EMD and LF/HF ratio (p=0.002). Esophageal motility disorders were prevalent (60.5%) in Type 2 diabetes and associated with autonomic nervous system dysfunction, including a higher LF/HF ratio (p=0.002).
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