Key result
Type 1 diabetics with parasympathetic neuropathy had significantly less R-R interval variation (29 vs 50; p=0.001) and higher postprandial motilin than those with normal function.
Population
109 diabetic patients (58 Type 1 and 51 Type 2)
Design
Cohort
Follow-up
7 years
Authors
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May link neuropathy to gut hormone changes in type 1 diabetes; hypothesis-generating and should not yet change practice.
Cohort (n=109)
Absolute Event Rate: 29% vs 50%
p-value: p=0.001
Nilsson et al. (1995) conducted a cohort in Type 1 and Type 2 diabetes (n=109). Parasympathetic neuropathy vs. Normal parasympathetic nerve function was evaluated on SD value of R-R intervals (p=0.001). Type 1 diabetics with parasympathetic neuropathy had significantly less R-R interval variation (29 vs 50; p=0.001) and higher postprandial motilin than those with normal function.
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