Why the study?
Cardiac autonomic neuropathy and diabetic peripheral neuropathy often develop early in T2DM and may remain silent, but the relationship between heart rate variability and nerve conduction studies in early-stage T2DM is not well defined.
Does early-stage type 2 diabetes mellitus associate with parallel cardiac autonomic and peripheral nerve dysfunction?
Population
100 patients with T2DM of less than five years duration (age 30-50 years) and 100 age- and sex-matched healthy controls
Comparison
T2DM patients vs age- and sex-matched healthy controls
Design
Cross-sectional study
Authors
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May warrant early autonomic and peripheral neuropathy screening in T2DM; extends evidence of onset within 5 years.
Does early-stage type 2 diabetes mellitus associate with parallel cardiac autonomic and peripheral nerve dysfunction?
Early-stage T2DM is associated with parallel autonomic and peripheral nerve dysfunction, with poor glycemic control and longer disease duration independently predicting autonomic impairment.
Siddiqui et al. (2026) studied this question.
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