Key result
Type 2 diabetes was associated with reduced heart rate variability (P<0.01 for total power) and increased subclinical atherosclerosis, with CIMT inversely associated with total power (P<0.01).
Why the study?
Is cardiac autonomic neuropathy associated with markers of subclinical atherosclerosis in patients with early type 2 diabetes?
Population
111 subjects free of coronary heart disease, comprising 57 with early type 2 diabetes mellitus and 54…
Comparison
Type 2 diabetes mellitus vs Nondiabetic control subjects
Design
Cross-sectional
Authors
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May link autonomic neuropathy to atherosclerosis risk in early T2DM; hypothesis-generating and requires prospective validation.
Observational (n=111)
Is cardiac autonomic neuropathy associated with markers of subclinical atherosclerosis in patients with early type 2 diabetes?
p-value: p=<0.01
Cardiac autonomic neuropathy is present in early T2DM and is independently associated with subclinical atherosclerosis markers such as increased CIMT.
Fakhrzadeh et al. (2012) conducted an observational in Type 2 diabetes mellitus (n=111). Type 2 diabetes mellitus vs. Nondiabetic subjects was evaluated on Heart rate variability (normalized HF power and total power) and markers of subclinical atherosclerosis (CIMT, CAC, FMD) (p=<0.01). Type 2 diabetes was associated with reduced heart rate variability (P<0.01 for total power) and increased subclinical atherosclerosis, with CIMT inversely associated with total power (P<0.01).
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