Key result
In patients with type 2 diabetes and coronary artery disease, the heart rate variability parameter SDANN demonstrated a significant independent negative correlation with Gensini scores (adjusted r = -0.23, P=0.03).
Why the study?
Cardiac autonomic neuropathy is a common and serious complication of diabetes mellitus with systemic involvements such as atherosclerotic cardiovascular disease, but its association with coronary artery lesions in type 2 diabetes needed evaluation.
Is cardiac autonomic neuropathy associated with the severity of coronary artery lesions in patients with type 2 diabetes?
Observational (n=104)
No
Is cardiac autonomic neuropathy associated with the severity of coronary artery lesions in patients with type 2 diabetes?
Answers are grounded in this paper and cite their sources.
Cardiac autonomic neuropathy, as measured by reduced heart rate variability (SDANN), is associated with a higher coronary atheromatous burden in patients with type 2 diabetes.
Objective. Cardiac autonomic neuropathy (CAN) is a common and serious complication of diabetes mellitus with various systemic involvements, such as atherosclerotic cardiovascular disease. We aimed to evaluate the association between CAN and coronary artery lesions in patients with type 2 diabetes. Research Design and Methods. We retrospectively reviewed the medical records of 104 patients with type 2 diabetes and coronary artery disease (CAD). We evaluated heart rate variability (HRV) parameters (SDANN, SDNN, and pNN50) to assess cardiac autonomic function. The severity of coronary lesions was assessed by the Gensini scores and the number of affected vessels. Correlation analyses between HRV parameters and the severity of coronary lesions and clinical parameters were performed. Results. Spearman’s correlation analysis showed a significant negative correlation between SDANN and Gensini scores ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"><a:mi>r</a:mi><a:mo>=</a:mo><a:mo>−</a:mo><a:mn>0.22</a:mn></a:math> , <c:math xmlns:c="http://www.w3.org/1998/Math/MathML" id="M2"><c:mi>P</c:mi><c:mo>=</c:mo><c:mn>0.03</c:mn></c:math> ). Interestingly, this finding remained significant after adjusting for clinical covariates ( <e:math xmlns:e="http://www.w3.org/1998/Math/MathML" id="M3"><e:mi>r</e:mi><e:mo>=</e:mo><e:mo>−</e:mo><e:mn>0.23</e:mn></e:math> , <g:math xmlns:g="http://www.w3.org/1998/Math/MathML" id="M4"><g:mi>P</g:mi><g:mo>=</g:mo><g:mn>0.03</g:mn></g:math> ). However, there was no association between HRV parameters and the severity of coronary lesions as assessed by the number of affected vessels. Clinical parameters were not significantly correlated with HRV parameters (all <i:math xmlns:i="http://www.w3.org/1998/Math/MathML" id="M5"><i:mi>P</i:mi><i:mo>></i:mo><i:mn>0.05</i:mn></i:math> ). Conclusions. Cardiac autonomic neuropathy might be related to the degree of coronary atheromatous burden in patients with type 2 diabetes. Screening for cardiac autonomic neuropathy might potentially be beneficial in the risk stratification of patients with type 2 diabetes.
No takes yet. Share an insight, caveat, or question.
Liu et al. (2020) conducted an observational in Type 2 diabetes and coronary artery disease (n=104). Cardiac autonomic neuropathy (reduced heart rate variability) vs. Normal heart rate variability was evaluated on Correlation between heart rate variability parameters (SDANN) and severity of coronary lesions (Gensini scores) (r = -0.23, p=0.03). In patients with type 2 diabetes and coronary artery disease, the heart rate variability parameter SDANN demonstrated a significant independent negative correlation with Gensini scores (adjusted r = -0.23, P=0.03).
Synapse has enriched 10 related papers. Consider them for comparative context: