Key result
Cardiac autonomic neuropathy is linked to ~46% higher rates of diastolic dysfunction in T2D.
Why the study?
Data showing the exact association between cardiac autonomic neuropathy and heart failure in diabetic patients are relatively scarce.
Is cardiac autonomic neuropathy associated with diastolic dysfunction in type 2 diabetic patients?
Observational (n=100)
Is cardiac autonomic neuropathy associated with diastolic dysfunction in type 2 diabetic patients?
Cardiac autonomic neuropathy is associated with a significantly higher prevalence of diastolic dysfunction in patients with type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Supports association of cardiac autonomic neuropathy with diastolic dysfunction in type 2 diabetes; leaves open causality and clinical utility pending prospective studies.
Aim: Cardiac autonomic neuropathy (CAN) is a common and important chronic complication in diabetic patients. Heart failure resulting from cardiomyopathy is also a lethal complication in diabetic patients. However, data showing the exact association between CAN and heart failure in diabetic patients are relatively scarce. Therefore, our study aimed to determine the association between the parameters assessing CAN and heart function in diabetic patients.Method: The medical records of type 2 diabetic patients who underwent an autonomic function test with heart rate variability (HRV) and echocardiography were reviewed from January 2018 to December 2018. A total of 100 type 2 diabetic patients were included, and the association between the parameters assessing CAN and heart function was analysed.Results: Among the 100 analysed patients, 65 were diagnosed with CAN and 26 showed diastolic dysfunction. Moreover, 19 (73.1%) diabetic patients with diastolic dysfunction were complicated with CAN. The occurrence of diastolic dysfunction was higher in diabetic patients with CAN than in diabetic patients without CAN (29.2% vs 20.0%, p < 0.05), and the occurrence of CAN was higher in diabetic patients with diastolic dysfunction than in patients without diastolic dysfunction (73.1% vs 62.2%, p < 0.05). However, there were no significant associations between HRV parameters and heart function.Conclusion: We demonstrated that diastolic dysfunction is more common in diabetic patients complicated with CAN than in diabetic patients without CAN, although several diabetic patients without diastolic dysfunction are also diagnosed with CAN. Moreover, further studies about the long-term serial monitoring of heart function according to the progression of CAN are required to confirm the exact association between CAN and heart function.
No takes yet. Share an insight, caveat, or question.
Lee et al. (2020) conducted an observational in Type 2 diabetes (n=100). Cardiac autonomic neuropathy vs. No cardiac autonomic neuropathy was evaluated on Diastolic dysfunction (p=< 0.05). Cardiac autonomic neuropathy was associated with a higher occurrence of diastolic dysfunction in type 2 diabetic patients compared to those without the condition.
Synapse has enriched 10 related papers. Consider them for comparative context: