Key result
New T2DM linked to ~9 bpm lower delta heart rate, indicating early parasympathetic dysfunction.
Why the study?
The prevalence of cardiac autonomic neuropathy in newly diagnosed type 2 diabetes mellitus patients varies widely and requires early detection and management.
Does newly diagnosed type 2 diabetes mellitus increase the prevalence of cardiac autonomic neuropathy compared to healthy controls?
Case-Control (n=70)
No
Does newly diagnosed type 2 diabetes mellitus increase the prevalence of cardiac autonomic neuropathy compared to healthy controls?
Absolute Event Rate: 21.11% vs 30.2%
p-value: p=0.00038
Cardiac autonomic neuropathy is prevalent even in newly diagnosed type 2 diabetes patients, highlighting the need for early screening using autonomic function tests.
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May support early CAN screening at T2DM diagnosis; extends regional prevalence data but remains hypothesis-generating.
Siddiqui et al. (2023) conducted a case-control in Type 2 Diabetes Mellitus (n=70). Type 2 Diabetes Mellitus vs. Healthy age-matched controls was evaluated on Delta Heart Rate (ΔHR) during autonomic function testing (p=0.00038). Newly diagnosed type 2 diabetes mellitus was associated with significantly reduced delta heart rate compared to healthy controls (21.11 vs 30.2 bpm; p=0.00038), indicating early parasympathetic autonomic dysfunction.