Key result
The time course of current of injury from onset to resolution was significantly correlated with the force needed to detach the active-fixation pacing lead from the myocardium in rabbits (r = 0.72, p<0.001).
Why the study?
Does the time course of current of injury correlate with acute stability of active-fixation pacing leads in rabbits?
Population
24 adult (2-2.5 months) male New Zealand White rabbits, weighing 3.2-3.6 kg
Comparison
Active-fixation pacing leads anchored with full… vs Active-fixation pacing leads anchored with…
Design
Preclinical, Rabbits randomly assigned to in vitro or in vivo study; lead…
Follow-up
Up to 60 minutes of monitoring
Authors
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Correlates current-of-injury time course with lead stability in rabbits; leaves open translation to clinical pacing practice.
Does the time course of current of injury correlate with acute stability of active-fixation pacing leads in rabbits?
Effect estimate: r = 0.72
p-value: p=<0.001
In a rabbit model, the persistence of the current of injury after active-fixation pacing lead placement correlates with acute lead stability, suggesting dynamic monitoring may be superior to a single assessment.
Shali et al. (2013) studied Pacemaker lead implantation (n=24). Active-fixation pacing leads with different rotation patterns vs. Contact vs half rotation vs full rotation was evaluated on Correlation between time course of current of injury (COI) and force needed to detach the lead from myocardium (r = 0.72, p=<0.001). The time course of current of injury from onset to resolution was significantly correlated with the force needed to detach the active-fixation pacing lead from the myocardium in rabbits (r = 0.72, p<0.001).
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