Key result
Acute tissue damage from continuous pacing led to the disappearance of the virtual electrode polarization effect and a significant increase in pacing thresholds, primarily driven by cell uncoupling.
Why the study?
Does acute tissue damage from strong current pacing alter stimulus-generated VEPs and pacing thresholds in rabbit hearts?
Population
Langendorff-perfused rabbit hearts (n=5)
Comparison
Acute tissue damage produced by continuous… vs Before tissue damage (baseline)
Design
Preclinical
Authors
Loading...
Tissue damage from strong pacing may abolish VEPs and raise thresholds; leaves open their role in clinical stimulation of damaged myocardium.
Does acute tissue damage from strong current pacing alter stimulus-generated VEPs and pacing thresholds in rabbit hearts?
Acute tissue damage from strong pacing currents eliminates virtual electrode polarization and increases pacing thresholds, primarily due to cell uncoupling.
Sambelashvili et al. (2004) studied Acute cardiac tissue damage (n=5). Continuous pacing with strong current vs. Baseline (before tissue damage) was evaluated on Virtual electrode polarization (VEP) patterns and pacing thresholds. Acute tissue damage from continuous pacing led to the disappearance of the virtual electrode polarization effect and a significant increase in pacing thresholds, primarily driven by cell uncoupling.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: