Key result
Clozapine attenuates lateral habenula-induced MAP increases by ~58% in anesthetized rats.
Why the study?
How the lateral habenula regulates autonomic cardiovascular control in stressful situations remains unclear.
Does the dopaminergic system mediate the autonomic cardiovascular responses induced by lateral habenula activation in rats?
Population
Urethane-anesthetized Wistar male rats
Comparison
Electrical stimulation of LHb with dopamine receptor antagonists or VTA inactivation
Design
Animal experimental study
Authors
Loading...
Dopamine receptor blockade attenuates LHb pressor responses in rats; hypothesis-generating for autonomic mediation, with no direct clinical implications.
Does the dopaminergic system mediate the autonomic cardiovascular responses induced by lateral habenula activation in rats?
Absolute Event Rate: 12.1% vs 28.9%
p-value: p=<0.001
The dopaminergic system, specifically involving the ventral tegmental area and dopamine D1-like and D2-like receptors, mediates the autonomic cardiovascular responses elicited by lateral habenula activation.
Sato et al. (2024) studied Autonomic cardiovascular responses (n=26). Clozapine (nonselective dopamine receptor antagonist) vs. Control (pre-drug baseline) was evaluated on Change in mean arterial pressure (MAP) induced by lateral habenula stimulation (p=<0.001). Administration of the nonselective dopamine receptor antagonist clozapine significantly attenuated the lateral habenula-induced mean arterial pressure increase from 28.9% to 12.1% in anesthetized rats.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: