What question did this study set out to answer?

Determine the dose-dependent nature of severe adverse effects associated with prazosin while evaluating clinical and skin prick sensitivity to common environmental spores and pollens.

August 28, 1976BMJOpen Access

Prazosin: severe side effects are dose-dependent.

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Authors

CRClive RosendorffSprint (United States)

Discussion

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Implication

Clinical study observes distinct fungal spore sensitivities alongside dose-dependent drug effects in patients, highlighting varying individual allergic reactivity.

Key Points

Determine the dose-dependent nature of severe adverse effects associated with prazosin while evaluating clinical and skin prick sensitivity to common environmental spores and pollens.
Assessed patient cohorts for severe adverse drug reactions following prazosin administration across different dosage levels.
Performed clinical evaluations and skin prick testing against specific fungal spores, including Phoma betae, Botrytis cinerea, and Cladosporium herbarum, alongside seasonal pollens.
Prick test sensitivity was observed for Phoma betae in 19 patients, Botrytis cinerea in 8 patients (3.2%), Cladosporium herbarum in 8 patients (2.9%), and Sporobolomyces roseum in 1 patient (0.4%).
No allergic reactions were observed clinically or through prick testing to Penicillium notatum, Ustilago tritici, or abundant seasonal pollens from nettle (Urtica) and plantain (Plantago).

Cite This Study

Clive Rosendorff (1976) studied this question.

synapsesocial.com/papers/6a157949d64fa333899fb5da https://doi.org/10.1136/bmj.2.6034.508

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Implication

Clinical study observes distinct fungal spore sensitivities alongside dose-dependent drug effects in patients, highlighting varying individual allergic reactivity.

Prazosin: severe side effects are dose-dependent.

Discussion

Member takes

Implication

Key Points

Cite This Study

Prazosin: severe side effects are dose-dependent.

Discussion

Member takes

Implication

Key Points

Cite This Study

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