Key result
An extended cardiorespiratory control model incorporating variable transport delays proposes several novel mechanisms for periodic breathing in clinical situations.
This computational modeling study identifies novel theoretical mechanisms for periodic breathing by incorporating variable transport delays dependent on cardiac output.
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Variable transport delays may explain periodic breathing; leaves open clinical relevance pending prospective validation.
In a previous publication (Fowler et al., 1993), we reduced the classical cardiorespiratory control model of (Grodins et al., 1967) to a much simpler form, which we then used to study the phenomenon of periodic breathing. In particular, cardiac output was assumed constant, and a single (constant) delay representing arterial blood transport time between lung and brain was included in the model. In this paper we extend this earlier work, both by allowing for the variability in transport delays, due to the dependence of cardiac output on blood gas concentrations, and also by including further delays in the system. In addition, we extensively discuss the physiological implications of parameter variations in the model; several novel mechanisms for periodic breathing in clinical situations are proposed. The results are discussed in the light of recent observational studies.
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A. C. Fowler (2000) studied Periodic breathing. Extended cardiorespiratory control model was evaluated. An extended cardiorespiratory control model incorporating variable transport delays proposes several novel mechanisms for periodic breathing in clinical situations.
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