Key result
A compartmental model of the cardiorespiratory system produced simulation responses to hypoxia, hypercapnia, and hemorrhage that agreed with physiological and theoretical data.
The presented integrated cardiorespiratory system model accurately simulates physiological responses to hypoxia, hypercapnia, and hemorrhage, providing a tool to understand regulatory mechanisms.
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Compartmental cardiorespiratory model with pulsatile flow and chemoreflex feedback; leaves open clinical translation pending validation studies.
A compartmental model of the cardiorespiratory system featuring pulsatile blood flow and gas transport, as well as closed loop mechanisms of cardiorespiratory regulation is presented. Short timescale regulatory action includes baroreflex, peripheral and central chemoreflex feedback. The cardiorespiratory model is composed by compartments to describe blood flow and gas exchange in the major systemic and pulmonic regions. The control systems include formulations to afferent activity of arterial baroreceptor and peripheral and central chemoreceptors. Simulations described here include situations of hypoxia, hypercapnia, and hemorrhage. The overall responses of our simulations agree with physiological (experimental) and theoretical data. Our results suggest that the present model could be used to further understand the interplay among major regulatory mechanisms in the functioning of the cardiovascular and respiratory systems in cases of normal and abnormal physiological conditions.
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Fernandes et al. (2020) studied this question. Simulations of hypoxia, hypercapnia, and hemorrhage was evaluated on Agreement of simulation responses with physiological and theoretical data. A compartmental model of the cardiorespiratory system produced simulation responses to hypoxia, hypercapnia, and hemorrhage that agreed with physiological and theoretical data.
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