Key result
Atherosclerotic plaque erosion drives acute coronary events and warrants distinct therapeutic strategies.
Why the study?
Plaque erosion contributes to a growing proportion of acute coronary events, but despite a heterogeneous substrate underlying coronary thrombosis, treatment remains identical.
This review highlights the mechanisms, clinical implications, and potential therapeutic strategies for atherosclerotic plaque erosion, a distinct mechanism contributing to acute coronary events.
Should not alter ACS management yet; leaves open whether erosion-targeted approaches improve outcomes.
Atherosclerosis is an insidious and progressive inflammatory disease characterized by the formation of lipid-laden plaques within the intima of arterial walls with potentially devastating consequences. While rupture of vulnerable plaques has been extensively studied, a distinct mechanism known as plaque erosion (PE) has gained recognition and attention in recent years. PE, characterized by the loss of endothelial cell lining in the presence of intact fibrous cap, contributes to a significant and growing proportion of acute coronary events. However, despite a heterogeneous substrate underlying coronary thrombosis, treatment remains identical. This article provides an overview of atherosclerotic PE characteristics and its underlying mechanisms, highlights its clinical implications, and discusses potential therapeutic strategies.
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Bruoha et al. (2024) conducted a review in Atherosclerotic Plaque Erosion. Atherosclerotic plaque erosion, characterized by endothelial loss over an intact fibrous cap, contributes significantly to acute coronary events and warrants distinct therapeutic strategies.
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