Key result
Plaque rupture is the most common substrate for coronary thrombosis and is associated with hypercholesterolemia, whereas plaque erosion is the prime cause in premenopausal women.
Design
Review
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May inform sex-specific ACS evaluation; leaves open prospective validation of tailored prevention strategies.
Highlights the distinct pathophysiological mechanisms and risk factors between plaque rupture and plaque erosion in coronary thrombosis.
A 1999 study conducted a review in Coronary thrombosis. Plaque rupture and plaque erosion was evaluated. Plaque rupture is the most common substrate for coronary thrombosis and is associated with hypercholesterolemia, whereas plaque erosion is the prime cause in premenopausal women.